Expert Session

Into the Bottle: Nightly Retinol Serum

September 23, 2025
Photos by: Bliss Kaufman

There’s nothing quite like Retinol for visibly firmer, smoother skin. And if you want to know why our Nightly Retinol Serum truly works, read on—we’re breaking it down with Oak’s Product Development Director, Gina Cruz. 

Why Is Retinol Considered a Gold-Standard Skincare Ingredient?

Retinol is considered a gold standard because it’s one of the most researched ingredients in skincare—with decades of in-vivo data behind it. In vivo testing means changes are measured on real skin. Studies have shown it supports epidermal renewal and collagen-related processes, which is why it reliably improves the look of texture, fine lines, and tone over time. Since Retinoids became more accessible over the counter, interest has surged—not just in potent formats, but also in gentler, more soothing Retinols that fit into a daily routine.  

What Kind of Results Can Someone Expect with Consistent Use?

With consistent use, you can expect smoother texture, a more even tone, and a softening in the look of fine lines as Retinol supports skin renewal and collagen-related processes. Results are cumulative, though, which is why we recommend using it nightly. Keep the bottle by your sink or nightstand as a cue to apply it every evening before bed. 

What Can Make Retinol Irritating? And Why Is Oak’s Formula More Gentle?

Retinol speeds up cell turnover, which brings newer, more delicate skin to the surface. In the process, your skin can feel sensitive—especially to UV—and some people experience redness, flaking, stinging, or itching. Potency also matters, as Retinoids come in different forms and strengths. While the more aggressive versions tend to work faster, they also can trigger more reactivity. 

Think of it as the same family of effects you would see with a chemical peel. Retinol is far milder, but it works along a similar renewal pathway. Which means that a measured, gradual approach key. 

For a gentler experience, Oak’s Nightly Retinol Serum is formulated with Retinol Ester at a lower relative strength, buffered with nourishing, barrier-supporting ingredients to help minimize skin disruption. My application guidance is as follows: 

  • Patch test first, and try it on a night when you’re not layering a lot of actives. 
  • Start 1–2 times per week, then increase the frequency as your skin tolerates. 
  • Always apply SPF in the morning! Retinol can make your skin more sun-sensitive. 

What Other Standout Ingredients Are in This Serum?

Beyond Retinol, we built the formula with Sodium Hyaluronate (a form of Hyaluronic Acid) to draw in moisture and plump, Linoleic Acid to support the skin barrier, and Tocopherol (Vitamin E) for antioxidant protection and formula stability. There’s also a five-extract complex—Rice Bran, Avocado, Rosemary Leaf, Magnolia Bark, and Sunflower—to help soothe, comfort, and provide additional antioxidant support against free radicals. For long-lasting hydration, we included Squalane, Coconut Oil, Glycerin, and Phospholipids in the formula.

What Is the Texture Like?

Nightly Retinol Serum has the thickest consistency of our three serums, and feels more like a lightweight moisturizer. It melts in and creates a breathable, protective veil on the skin with a time-released effect that works throughout the night.

Who Should Use This Serum?

Nightly Retinol Serum is great for most skin types looking to smooth texture and refine tone. As we age, natural cell turnover slows—it's about 28 days in the teens/early 20s, 30–40 days in the 30s, and 45–60+ days in the 40s and beyond. This is why adding a gentle retinol to your routine helps keep renewal on track. If you’re in your 30s, think of Retinol as a preventative measure. In your 40s and beyond, Nightly Retinol Serum is the perfect evening staple.